The Henry M. Jackson Foundation for the Advancement of Military Medicine

Advancing Military Medicine

Search Results - variants

3 Results Sort By:
Novel, Cross-Sarbecovirus Neutralizing and Binding Monoclonal Antibodies (mAbs) (HJF 660-23)
The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine elicited protection highlights the need to develop vaccine candidates with broad protection. Current invention identified six neutralizing antibodies with broad sarbecovirus cross-reactivity. This finding has applications towards developing next-generation...
Published: 5/9/2025   |   Inventor(s): Kerri Lal, Shelly Krebs, Samantha Townsley, Michael Gordon Joyce, Vincent Dussupt
Keywords(s): Antibody, Coronavirus, Cross-Reactivity, Ferritin, Infectious Disease, Nano-particle, Neutralizing Antibodies, Respiratory, Sarbecovirus, SpFN, Spike Proteins, Vaccines, Variants, Viral
Category(s): Research Tool
Monoclonal Antibodies Against Coronavirus and Their Uses - (HJF 595-21)
Researchers at HJF and the Walter Reed Army Institute of Research (WRAIR) have discovered new human and recombinant monoclonal antibodies (mAbs) that show broad cross reactivity among coronavirus variants with potential applications in diagnostics and therapeutics for coronavirus. Applications and Advantages Discovered antibodies can be used in...
Published: 3/14/2025   |   Inventor(s): Shelly Krebs, Kayvon Modjarrad, Nelson Michael, Vincent Dussupt, Gina Donofrio, Samantha Townsley
Keywords(s): Coronavirus, COVID-19, Cross-Reactivity, Monoclonal Antibodies, Respiratory, SARS, SARS-CoV-2, Spike Proteins, Vaccines, Variants
Category(s): Diagnostics, Therapeutic
Vaccines against SARS-COV-2 and other Coronaviruses - (HJF 569-20 & HJF 635-22)
Researchers at HJF and the Walter Reed Army Institute of Research (WRAIR) have developed novel vaccines comprised of fusion proteins; Ferritin nanoparticle and antigenic coronavirus peptide(s). These fusion proteins generate simultaneous protective neutralizing immune responses against coronaviruses and their variants. Applications and Advantages Innovation...
Published: 3/14/2025   |   Inventor(s): Kayvon Modjarrad, Michael Gordon Joyce
Keywords(s): Coronavirus, COVID-19, Nano-particle, SARS-CoV-2, Self-Assembly, Vaccines, Variants
Category(s): Diagnostics, Therapeutic