The Henry M. Jackson Foundation for the Advancement of Military Medicine

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Search Results - status+epilepticus

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Isoflurane Administration as a Method for Neuroprotection in Organophosphate Poisoning (HJF 620-22 and HJF 441-16)
Organophosphate-based chemical agents (OPs), including nerve agents and certain neurotoxic pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and prolonged seizures, including progression to status epilepticus, potentially leading to irreversible central nervous system (CNS) damage if not treated promptly....
Published: 5/9/2025   |   Inventor(s): Aryan Namboodiri, John Moffett, Narayanan Vasudevan
Keywords(s): CNS, Neuroprotection, Organophosphate, Pesticide Poisoning, Seizure, Status Epilepticus
Category(s): Therapeutic, Medical Device
Novel Drug Combination Treatment for Nerve Agent and Organophosphate Poisoning in Children - (HJF 447-16)
Organophosphates (OP) which include pesticides and nerve agents are a common source of poisoning with approximately 3 million worldwide exposures each year and around 300,000 resulting deaths. Researchers at the Uniformed Services University of the Health Sciences (USUHS) have developed a novel treatment formulation to treat CNS symptoms including status...
Published: 2/24/2025   |   Inventor(s): Maria F.M. Braga, Vassiliki Aroniadou-Anderjaska
Keywords(s): CNS, Nerve Agent, Organophosphate, Pediatric, Poison, Seizure, Status Epilepticus
Category(s): Therapeutic