The Henry M. Jackson Foundation for the Advancement of Military Medicine

Advancing Military Medicine

Search Results - sarbecovirus

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Novel, Cross-Sarbecovirus Neutralizing and Binding Monoclonal Antibodies (mAbs) (HJF 660-23)
The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine elicited protection highlights the need to develop vaccine candidates with broad protection. Current invention identified six neutralizing antibodies with broad sarbecovirus cross-reactivity. This finding has applications towards developing next-generation...
Published: 5/9/2025   |   Inventor(s): Kerri Lal, Shelly Krebs, Samantha Townsley, Michael Gordon Joyce, Vincent Dussupt
Keywords(s): Antibody, Coronavirus, Cross-Reactivity, Ferritin, Infectious Disease, Nano-particle, Neutralizing Antibodies, Respiratory, Sarbecovirus, SpFN, Spike Proteins, Vaccines, Variants, Viral
Category(s): Research Tool
Shark Antibodies and Shark-Derived Binding Domains Specific for the SARS-CoV-2 Coronavirus - (HJF 581-20)
HJF scientists have developed a series of single variable domain antibodies (nanobodies or VNARs, derived from nurse sharks) specifically targeting SARS-CoV-2 and other betacoronaviruses, thus providing unique therapeutics and diagnostics for COVID-19 and possibly other betacoronavirus infections. Applications and Advantages Fully sequenced, grafted...
Published: 7/3/2025   |   Inventor(s): Michael Gordon Joyce, Kayvon Modjarrad, Helen Dooley
Keywords(s): Antibody, Coronavirus, COVID-19, Diagnostics, Sarbecovirus, SARS-CoV-2, Therapeutics
Category(s): Therapeutic, Diagnostic