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A Urine-based Method to Isolate and Detect Prostate Cancer Cells Using Immunohistochemical Analysis (HJF 247-10)
Background
Current methods for detecting prostate cancer can lack sensitivity and specificity, particularly when analyzing low concentrations of cells in biological samples. Existing diagnostic techniques may require invasive procedures or fail to efficiently recover and identify cancer cells from urine samples.
There remains a need for improved methods...
Published: 7/15/2026
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Updated: 5/28/2026
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Inventor(s): Shiv Srivastava, Gyorgy Petrovics, Shyh-Han Tan, Kristen Nickens
Keywords(s): Biomarker, Cancer, Cell Line, Diagnostics, Immunohistochemistry, Prostate Cancer, PSA
Category(s): Diagnostic
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ETV4 Mouse Monoclonal Antibodies - (HJF 551-19)
Researchers at the Henry M. Jackson Foundation (HJF) have developed a Mouse monoclonal antibody (mAb) that that reacts specifically against the human ETS Translocation Variant 4 (ETV4) transcription factor protein. Research indicates a correlation between strong ETV protein expression and poor outcomes in several cancers. The antibody can be used to...
Published: 7/16/2026
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Updated: 2/27/2026
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Inventor(s): Shyh-Han Tan
Keywords(s): ERG, ETS, ETV4, Monoclonal Antibodies, Prostate Cancer
Category(s): Research Tool, Diagnostic
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Race/Ethnicity associated Biomarkers for Prostate Cancer (HJF 527-18)
Research focused on identifying Race/Ethnicity associated differences of prostate cancer led to the discovery of distinct similarities and differences in gene alterations of African American (AA) and Caucasian American (CA) prostate cancer patients (CaP). These results could lead to the development of a prognostic assay that stratifies newly diagnosed...
Published: 5/18/2026
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Updated: 11/26/2025
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Inventor(s): Albert Dobi, Hua Li, Isabell Sesterhenn, Zoltan Szallasi, Shiv Srivastava
Keywords(s): Genomic Alterations, LSAMP, Prostate Cancer, PTEN, Race/Ethnicity Associated Biomarkers,, Recurrence
Category(s): Diagnostic
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Prostate Cancer Gene Profiles (HJF 346-13)
Prostate cancer (PCa) has the highest heritability and widest racial disparities of any cancer. African Americans (AAs) in the United States are known to have a higher incidence and mortality for PCa compared to Caucasian Americans (CAs).
Researchers at the Henry M. Jackson Foundation (HJF), Uniformed Services University for Health Sciences (USU),...
Published: 5/5/2026
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Updated: 6/11/2025
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Inventor(s): Shiv Srivastava, Albert Dobi, Gyorgy Petrovics, Thomas Werner, Martin Seifert, Matthias Scherf
Keywords(s): African American, Ethnic-Specific Genes, Genome Sequencing, Mortality, Prostate Cancer, Prostate Cancer Incidence
Category(s): Diagnostic
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ETV1 Monoclonal Antibodies - (HJF 641-23)
ETV1 is a protein of Erythroblast Transformation Specific (ETS) family of transcription factors. Dysregulation of ETV-1 has been observed in many malignancies including, gastrointestinal stromal (GIS), prostatic tumors, and in triple-negative breast cancer.
Researchers at HJF and the Uniformed Services University for the Health Sciences (USU) have...
Published: 7/1/2026
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Updated: 4/11/2023
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Inventor(s): Shyh-Han Tan, Albert Dobi, Shiv Srivastava
Keywords(s): ERG, Monoclonal Antibodies, Prostate Cancer
Category(s): Research Tool, Diagnostic
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Small Molecule Inhibitors of ERG Oncoprotein - (HJF 578-20, HJF 393-15, and HJF 324-13)
HJF scientists have developed a first-in-class family of novel and potent small molecule ERG inhibitors that can be used as targeted therapeutics for malignant diseases with overexpression of ERG oncoproteins. Therapeutic indications may include prostate cancer, leukemia, and colorectal cancer.
Applications and Advantages
First-in-class small molecule...
Published: 7/16/2026
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Updated: 2/2/2023
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Inventor(s): Albert Dobi, Sanjay Malhotra, Mallesh Pandrala, Binil Eldhose
Keywords(s): Cancer, Colorectal Cancer, ERG, Leukemia, Oncogene, Prostate Cancer, Small Molecule, Therapeutics
Category(s): Therapeutic
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Urine-Based Prostate Cancer Diagnostics - (HJF 485-17)
A technology for screening and diagnosing prostate cancer based on urine exosomes is available for licensing from HJF.
Applications and Advantages
Screening for and diagnosis prostate cancer with superior accuracy than the standard of care.
Convenience of using regular urine sample that can be collected at home, as opposed to post-DRE urine sample.
RNA...
Published: 7/16/2026
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Updated: 2/2/2023
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Inventor(s): Shiv Srivastava, Gyorgy Petrovics, Indu Kohaar
Keywords(s): Diagnostics, Prostate Cancer
Category(s): Diagnostic
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