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A Urine-based Method to Isolate and Detect Prostate Cancer Cells Using Immunohistochemical Analysis (HJF 247-10)
Background
Current methods for detecting prostate cancer can lack sensitivity and specificity, particularly when analyzing low concentrations of cells in biological samples. Existing diagnostic techniques may require invasive procedures or fail to efficiently recover and identify cancer cells from urine samples.
There remains a need for improved methods...
Published: 5/28/2026
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Updated: 5/28/2026
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Inventor(s): Shiv Srivastava, Gyorgy Petrovics, Shyh-Han Tan, Kristen Nickens
Keywords(s): Biomarker, Cancer, Cell Line, Diagnostics, Immunohistochemistry, Prostate Cancer, PSA
Category(s): Diagnostic
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Prediction of Venous Thromboembolism Utilizing Machine Learning Models - (HJF 477-17)
Background
Individuals exposed to physical trauma, including battlefield injuries and major accidents, have an elevated risk of developing venous thromboembolism (VTE). Existing diagnostic approaches can be difficult to apply in acute trauma settings because robust and invasive diagnostic methods may not be feasible in the field or at the bedside....
Published: 5/28/2026
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Updated: 5/28/2026
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Inventor(s): Eric Elster, John Oh, Beverly Gaucher, Seth Schobel-McHugh
Keywords(s): Biomarker, Clinical Decision Support Systems, Machine Learning, Predictive Modeling, Trauma, Venous Thromboembolism
Category(s): Diagnostic
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Use of Machine Learning Models for Prediction of Clinical Outcomes (HJF 529-18)
Background
Individuals exposed to physical trauma, including battlefield injuries and major accidents, are at elevated risk of severe complications. Existing diagnostic approaches can make it difficult to accurately quantify clinical risk and guide treatment decisions, particularly in environments where advanced diagnostics are unavailable. Early identification...
Published: 5/28/2026
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Updated: 5/28/2026
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Inventor(s): Seth Schobel-McHugh, Matthew Bradley
Keywords(s): Biomarker, Critical Care, Diagnostics, Machine Learning, Random Forest Model, Respiratory, Respiratory Distress, Sepsis, Traumatic Brain Injury
Category(s): Diagnostic
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Rapid, Point-of-care Sepsis Mortality Prediction System – (HJF 655-23)
Researchers at the Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) have developed systems and methods for predicting sepsis mortality risk using biomarker data and clinical parameters.
Applications and Advantages
Enables early and accurate prediction of sepsis mortality risk.
Supports improved clinical decision-making...
Published: 5/26/2026
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Updated: 5/21/2026
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Inventor(s): Danielle Clark, Joost Brandsma, Joshua Chenoweth, Deborah Striegel
Keywords(s): Clinical Decision Support Systems, Critical Care, Diagnostics, Gene Expression Assays, Machine Learning, Point of Care, Sepsis
Category(s): Diagnostic
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Biomarkers for Posttraumatic Stress Disorder (PTSD) - (HJF 356-13)
Introduction
Researchers at the Uniformed Services University of the Health Sciences (USUHS) have developed methods, kits and biomarkers based on microRNA (miRNA) measurements in human biological samples to detect, diagnose, monitor progression of, and potentially guide treatment for posttraumatic stress disorder (PTSD).
Applications and Advantages
Clinical...
Published: 5/21/2026
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Updated: 5/21/2026
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Inventor(s): Harvey Pollard, Roopa Biswas
Keywords(s): Biomarker, CSF, Diagnostic Kit, microRNA, miRNA, Monitoring, Plasma, qRT PCR, Ratio Biomarker, Time-of-day-sampling, Treatment Response
Category(s): Diagnostic
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ETV4 Mouse Monoclonal Antibodies - (HJF 551-19)
Researchers at the Henry M. Jackson Foundation (HJF) have developed a Mouse monoclonal antibody (mAb) that that reacts specifically against the human ETS Translocation Variant 4 (ETV4) transcription factor protein. Research indicates a correlation between strong ETV protein expression and poor outcomes in several cancers. The antibody can be used to...
Published: 4/21/2026
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Updated: 2/27/2026
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Inventor(s): Shyh-Han Tan
Keywords(s): ERG, ETS, ETV4, Monoclonal Antibodies, Prostate Cancer
Category(s): Research Tool, Diagnostic
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Peptides and Vaccines to inhibit Gonorrhoeae - (HJF 301-12)
Gonorrhoeae, a mucosal pathogen of the lower urogenital tract is remarkable in its capacity for antibiotic resistance. Its Multiple Transferable Resistance system (MTr) is known to enhance pathogen survival. Researchers at the Uniformed Services University (USU) and the Henry M. Jackson Foundation (HJF) have isolated the MtrE protein with possible application...
Published: 4/21/2026
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Updated: 1/16/2026
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Inventor(s): Ann Jerse, Amanda DeRocco
Keywords(s): Antibiotic Resistance, Antibodies, Antimicrobial, Inoculate, Neisseria gonorrhoeae, Peptide, Urogenital Tract, Vaccines
Category(s): Diagnostic, Therapeutic
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System and Method for Predicting Pulmonary and Other Complications Following Rib Fractures - (HJF 690-24)
Introduction
Scientists at the Henry M. Jackson Foundation (HJF), the Uniformed Services University of the Health Sciences (USUHS), and Duke University (Duke) have developed innovative systems, methods, and computational models designed to predict clinical complications such as acute lung injury (ALI), acute kidney injury (AKI), pneumonia, and respiratory...
Published: 3/20/2026
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Updated: 12/19/2025
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Inventor(s): Joseph Fernandez-Moure, Seth Schobel-McHugh, Scott Grey, Renhua Li, Eric Elster
Keywords(s): Acute Kidney Injury (AKI), Acute Lung Injury (ALI), Biomarker, CDST, Chemokines, Cytokines, Immune Response Dynamics, Injury Trauma Prediction, Machine Learning, Personalized Treatment, Respiratory Distress
Category(s): Diagnostic
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Race/Ethnicity associated Biomarkers for Prostate Cancer (HJF 527-18)
Research focused on identifying Race/Ethnicity associated differences of prostate cancer led to the discovery of distinct similarities and differences in gene alterations of African American (AA) and Caucasian American (CA) prostate cancer patients (CaP). These results could lead to the development of a prognostic assay that stratifies newly diagnosed...
Published: 5/18/2026
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Updated: 11/26/2025
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Inventor(s): Albert Dobi, Hua Li, Isabell Sesterhenn, Zoltan Szallasi, Shiv Srivastava
Keywords(s): Genomic Alterations, LSAMP, Prostate Cancer, PTEN, Race/Ethnicity Associated Biomarkers,, Recurrence
Category(s): Diagnostic
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Method for Enrichment of Neuronally Derived Extracellular Vesicles (HJF 694-24)
Researchers at the Henry M. Jackson Foundation (HJF) and the Uniformed Services University of the Health Sciences (USU) identified a novel marker (ICAM-5) for enriching neuronally derived extracellular vesicles (NEVs) from human biofluids. NEVs can address key challenges in biomarker identification for neurological disorders.
Applications and Advantages
The...
Published: 5/28/2026
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Updated: 10/20/2025
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Inventor(s): Manish Bhomia, Barbara Knollmann-Ritschel
Keywords(s): Alzheimer's Disease, Parkinson's Disease, Traumatic Brain Injury
Category(s): Diagnostic
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