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Prostate Cancer Gene Profiles (HJF 346-13)
Prostate cancer (PCa) has the highest heritability and widest racial disparities of any cancer. African Americans (AAs) in the United States are known to have a higher incidence and mortality for PCa compared to Caucasian Americans (CAs).
Researchers at the Henry M. Jackson Foundation (HJF), Uniformed Services University for Health Sciences (USU),...
Published: 7/2/2025
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Inventor(s): Shiv Srivastava, Albert Dobi, Gyorgy Petrovics, Thomas Werner, Martin Seifert, Matthias Scherf
Keywords(s): African American, Ethnic-Specific Genes, Genome Sequencing, Mortality, Prostate Cancer, Prostate Cancer Incidence
Category(s): Diagnostic
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Phosphopeptide Signatures Predicting Basal-Like Breast Cancer Recurrence - (HJF 652-23)
Seventeen (17) phosphopeptides that are significantly differentially expressed between relapsed and relapse-free basal-like breast cancer (BC) tissues, were identified and used to develop a prognostic model with a recurrence index score. This recurrence index score could identify cases of relapsed and relapse-free basal-like BC with a significant difference...
Published: 7/3/2025
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Inventor(s): Albert Kovatich, Hai Hu, Praveen Kumar, Craig Shriver
Keywords(s):
Category(s): Diagnostic
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Non-invasive Clinical Decision Support Tool to Predict Allograft Rejection (HJF 662-23)
Vascularized Composite Allotransplantation (VCA) is a reconstructive option that involves transplantation of composite tissues, such as skin, muscle, and bone, in one surgical procedure. However, graft rejection remains a major challenge that needs to be addressed to improve patient outcomes.
To address this challenge, scientists at Johns Hopkins University...
Published: 5/29/2025
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Inventor(s): Renhua Li, Gerald Brandacher, Eric Elster, Seth Schobel-McHugh, Byoung Chol Oh
Keywords(s): Allograft rejection, Graft Failure, Reconstruction
Category(s): Diagnostic
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Diagnostic Tool for High-grade Serous Ovarian Cancer - (HJF 616-21)
Researchers at HJF, Inova Fairfax Hospital (IFH), and the Peter MacCallum Cancer Centre (PMCC) have identified orthogonal protein and transcript-based biomarkers correlating with Homologous Recombination Deficiency (HRD). This may lead to a companion clinical diagnostic assay to prioritize High-Grade Serous Ovarian Cancer (HGSOC) patients for targeted...
Published: 7/3/2025
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Inventor(s): Nicholas Bateman, Tamara Abulez, Thomas Conrads, George Larry Maxwell, Dale Garsed, David Bowtell, Ahwan Pandey
Keywords(s): Assay, Biomarker Assay, Companion Diagnostic, DDR, DNA Damage Repair, HGSOC, High-Grade Serous Ovarian Carcinoma, Ovarian Cancer, PARP Inhibitors
Category(s): Therapeutic, Diagnostic
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Immunogens and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus immunogen that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge.
Applications...
Published: 7/3/2025
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Inventor(s): Shelly Krebs, Vincent Dussupt
Keywords(s): Dengue, Flavivirus, Immunogen, Vaccines, Zika
Category(s): Therapeutic, Diagnostic, Research Tool
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DNA Damage Repair Genes in Prostate Cancer - (HJF 557-19)
Prostate cancer patients with DDRG mutations are increasingly considered for targeted cancer therapies. Currently available DDRG mutation tests rely on a rather small number of genes which are not often mutated in African American prostate cancer patients. This invention describes a robust data set on inherited mutations which can be used to develop...
Published: 7/9/2025
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Inventor(s): Gyorgy Petrovics, Shiv Srivastava
Keywords(s): African American, Caucasian, DDRG, Mutation, Precision Therapy, Prostate Cancer
Category(s): Diagnostic
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Predictive Tool on Probability of Successful Wound Closure - (HJF 637-22)
Greater than 20% of traumatic wound closure attempts fail due to the immuno-molecular status of the healing wound tissue.
Researchers at HJF and the Uniformed Services University for Health Sciences (USU) developed a product that analyzes the individual's wound healing immune response and computes a risk of failure score based on cytokine levels...
Published: 5/29/2025
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Inventor(s): Seth Schobel-McHugh, Eric Elster, Henry Robertson, Felipe Lisboa, Michael Rouse, Scott Grey
Keywords(s): Biomarker, CDST, Dehisced Wound, Effluent, Healing, Serum, Wound, Wound Closure, Wound Failure
Category(s): Diagnostic
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ETV1 Monoclonal Antibodies - (HJF 641-23)
ETV1 is a protein of Erythroblast Transformation Specific (ETS) family of transcription factors. Dysregulation of ETV-1 has been observed in many malignancies including, gastrointestinal stromal (GIS), prostatic tumors, and in triple-negative breast cancer.
Researchers at HJF and the Uniformed Services University for the Health Sciences (USU) have...
Published: 7/3/2025
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Inventor(s): Shyh-Han Tan, Albert Dobi, Shiv Srivastava
Keywords(s): ERG, Monoclonal Antibodies, Prostate Cancer
Category(s): Research Tool, Diagnostic
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Monoclonal Antibodies Against Coronavirus and Their Uses - (HJF 595-21)
Researchers at HJF and the Walter Reed Army Institute of Research (WRAIR) have discovered new human and recombinant monoclonal antibodies (mAbs) that show broad cross reactivity among coronavirus variants with potential applications in diagnostics and therapeutics for coronavirus.
Applications and Advantages
Discovered antibodies can be used in...
Published: 3/14/2025
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Inventor(s): Shelly Krebs, Kayvon Modjarrad, Nelson Michael, Vincent Dussupt, Gina Donofrio, Samantha Townsley
Keywords(s): Coronavirus, COVID-19, Cross-Reactivity, Monoclonal Antibodies, Respiratory, SARS, SARS-CoV-2, Spike Proteins, Vaccines, Variants
Category(s): Therapeutic, Diagnostic
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Shark Antibodies and Shark-Derived Binding Domains Specific for the SARS-CoV-2 Coronavirus - (HJF 581-20)
HJF scientists have developed a series of single variable domain antibodies (nanobodies or VNARs, derived from nurse sharks) specifically targeting SARS-CoV-2 and other betacoronaviruses, thus providing unique therapeutics and diagnostics for COVID-19 and possibly other betacoronavirus infections.
Applications and Advantages
Fully sequenced, grafted...
Published: 7/3/2025
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Inventor(s): Michael Gordon Joyce, Kayvon Modjarrad, Helen Dooley
Keywords(s): Antibody, Coronavirus, COVID-19, Diagnostics, Sarbecovirus, SARS-CoV-2, Therapeutics
Category(s): Therapeutic, Diagnostic
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