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The Henry M. Jackson Foundation for the Advancement of Military Medicine
Advancing Military Medicine
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Filarial Intestinal Antigens as Vaccine Candidates and Testing in Novel Animal Model of Filariasis - (HJF 378-14)
Introduction Filariae are tissue-invasive parasitic nematodes that cause human diseases such as lymphatic filariasis, river blindness and African eyeworm; affecting over 200 million people worldwide. In addition to human disease, filarial parasites infect dogs and cats causing heartworm infections. Currently, no vaccine exists to prevent either human...
Published: 10/29/2025
|
Inventor(s):
Edward Mitre
,
Christopher Morris
,
Sasisekhar Bennuru
,
Thomas Nutman
Keywords(s):
Category(s):
Research Tool
,
Therapeutic
Preventing and Treating Filarial Disease - (HJF 470-17)
Filarial worms are thread-like parasites that cause severe damage to the lymphatic system as manifested by painful and abnormal swelling of body parts. Current strategies to stop infection includes annual Mass Drug Administration (MDA) to the entire at-risk population (human and animal) for 6-10 years. However, the drugs used currently have limited...
Published: 12/8/2025
|
Inventor(s):
Edward Mitre
,
Alexander Flynn
,
Christopher Morris
,
Thomas Nutman
,
Sasisekhar Bennuru
Keywords(s):
Category(s):
Therapeutic