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Complex Natural Homogenates for Treating Allergies and Autoimmune Diseases (HJF 357-13)
Studies in humans and animals have demonstrated that infection with parasitic worms is protective against a range of chronic inflammatory diseases. These include inflammatory bowel disease, environmental allergies, asthma, and autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. Parasitic worm infections modulate...
Published: 11/7/2025
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Inventor(s): Edward Mitre, Marina Torrero, Belinda Jackson
Keywords(s): Immune Balance, Natural Supplement, Nutraceutical Development, Safe Immune Modulation, Type 1 Diabetes Prevention, Worm Extract
Category(s): Therapeutic
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Filarial Intestinal Antigens as Vaccine Candidates and Testing in Novel Animal Model of Filariasis - (HJF 378-14)
Introduction
Filariae are tissue-invasive parasitic nematodes that cause human diseases such as lymphatic filariasis, river blindness and African eyeworm; affecting over 200 million people worldwide. In addition to human disease, filarial parasites infect dogs and cats causing heartworm infections. Currently, no vaccine exists to prevent either human...
Published: 10/29/2025
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Inventor(s): Edward Mitre, Christopher Morris, Sasisekhar Bennuru, Thomas Nutman
Keywords(s):
Category(s): Research Tool, Therapeutic
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Molecular Predictors of Lung Adenocarcinoma Survival (HJF 602-21)
Research by Henry M. Jackson Foundation (HJF), Uniformed Services University (USU), and Defense Health Agency (DHA) scientists focused on identifying protein and RNA expression signatures that can differentiate between aggressive and metastasis-free lung adenocarcinoma (LUAD) tumors. These signatures were validated against National Cancer Institute’s...
Published: 8/11/2025
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Inventor(s): Matthew Wilkerson, Robert Browning Jr, Craig Shriver
Keywords(s):
Category(s): Therapeutic
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Isoflurane Administration as a Method for Neuroprotection in Organophosphate Poisoning (HJF 620-22 and HJF 441-16)
Organophosphate-based chemical agents (OPs), including nerve agents and certain neurotoxic pesticides such as paraoxon, are potent acetylcholinesterase inhibitors that cause severe convulsions and prolonged seizures, including progression to status epilepticus, potentially leading to irreversible central nervous system (CNS) damage if not treated promptly....
Published: 9/15/2025
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Inventor(s): Aryan Namboodiri, John Moffett, Narayanan Vasudevan
Keywords(s): CNS, Neuroprotection, Organophosphate, Pesticide Poisoning, Seizure, Status Epilepticus
Category(s): Therapeutic, Medical Device
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Small Molecule Therapeutics for Acute Myeloid Leukemia and Solid Tumors (HJF 490-17)
A technology related to novel methods of using small molecule compounds for treating myeloid neoplasms and solid tumor is available for licensing or collaboratively developing from HJF.
Applications and Advantages
Novel therapeutic targets for treating AML
Targeted therapy for cancer patients with overexpression or activating mutation of SETBP1
Innovation...
Published: 7/24/2025
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Inventor(s): Yang (Dennis) Du, Nhu Nguyen
Keywords(s):
Category(s): Therapeutic
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Novel Vaccine Enhancers - (HJF 642-23)
Researchers at Henry M. Jackson Foundation (HJF), Uniformed Services University of the Health Sciences (USU), and Leidos Biomedical Research, Inc. (Leidos) have developed improvements to the effectiveness of mRNA vaccines. Such enhancements could reduce the number of doses needed for maximal protection, enhance vaccine durability, and reduce associated...
Published: 7/22/2025
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Inventor(s): Edward Mitre, Elizabeth Graydon, Stephen Anderson
Keywords(s): mRNA, Therapeutics, Vaccines
Category(s): Therapeutic
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Diagnostic Tool for High-grade Serous Ovarian Cancer - (HJF 616-21)
Researchers at HJF, Inova Fairfax Hospital (IFH), and the Peter MacCallum Cancer Centre (PMCC) have identified orthogonal protein and transcript-based biomarkers correlating with Homologous Recombination Deficiency (HRD). This may lead to a companion clinical diagnostic assay to prioritize High-Grade Serous Ovarian Cancer (HGSOC) patients for targeted...
Published: 8/22/2025
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Inventor(s): Nicholas Bateman, Tamara Abulez, Thomas Conrads, George Larry Maxwell, Dale Garsed, David Bowtell, Ahwan Pandey
Keywords(s): Assay, Biomarker Assay, Companion Diagnostic, DDR, DNA Damage Repair, HGSOC, High-Grade Serous Ovarian Carcinoma, Ovarian Cancer, PARP Inhibitors
Category(s): Therapeutic, Diagnostic
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Lymphocyte Antigen 6 (Ly6) Targeted Cancer Immunotherapy - (HJF 649-23)
A technology related to using antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) transduced immune cells that selectively targets Ly6 family of proteins overexpressed in cancer cells and has the potential to be effective in treating ovarian, colorectal, gastric, breast, and lung cancer without off-target effects. This HJF technology...
Published: 5/23/2025
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Inventor(s): Geeta Upadhyay
Keywords(s): Antibody, Antibody Conjugates, Antibody Drug Conjugate, Cancer, CAR, Ly6, Lymphocite Antigen 6
Category(s): Therapeutic
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Immunogens and Vaccine Components Against HIV - (HJF 630-22)
HJF researchers have developed a novel vaccine strategy against HIV-1. These vaccine candidates are designed to elicit broadly neutralizing antibodies that could protect against a wide variety of HIV strains.
Applications and Advantages
Novel vaccine design approach that emulates the diversity observed in HIV-1 infections with multiple founder variants
Vaccine...
Published: 5/29/2025
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Inventor(s): Morgane Rolland, Eric Lewitus, Hongjun Bai
Keywords(s): Antibody, Assay, bnAbs, CD4, Env, HIV, Vaccines
Category(s): Therapeutic
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Immunogens and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus immunogen that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge.
Applications...
Published: 7/24/2025
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Inventor(s): Shelly Krebs, Vincent Dussupt
Keywords(s): Dengue, Flavivirus, Immunogen, Vaccines, Zika
Category(s): Therapeutic, Diagnostic, Research Tool
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