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Human T-lymphoblastoid Derived A3R5 cell line - (HJF 516-18)
This invention relates to the A3R5.7 (designated A3R5) cell line that supports the detection of HIV-1-specific neutralization by mAbs, sCD4 and polyclonal plasma across wide range of epitopes on the HIV-1 envelope.
Applications and Advantages
Tool for analysis of neutralization activity in HIV vaccine trials
Supports an extensive range of HIV-1...
Published: 11/18/2025
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Inventor(s): Jerome Kim, Robert McLinden
Keywords(s):
Category(s): Research Tool
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Filarial Intestinal Antigens as Vaccine Candidates and Testing in Novel Animal Model of Filariasis - (HJF 378-14)
Introduction
Filariae are tissue-invasive parasitic nematodes that cause human diseases such as lymphatic filariasis, river blindness and African eyeworm; affecting over 200 million people worldwide. In addition to human disease, filarial parasites infect dogs and cats causing heartworm infections. Currently, no vaccine exists to prevent either human...
Published: 10/29/2025
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Inventor(s): Edward Mitre, Christopher Morris, Sasisekhar Bennuru, Thomas Nutman
Keywords(s):
Category(s): Research Tool, Therapeutic
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Lentivirus Immortalizing Vertebrate Macrophages, (LIVeMac) HJF 512-18
Researchers at Uniformed Services University (USU) and the Henry M. Jackson Foundation (HJF) have developed a replication-deficient, infection competent viral vector for immortalizing mammalian macrophages. On further development, this lentiviral vector could infect all mammalian cells and can immortalize macrophages from diverse species.
Applications...
Published: 7/24/2025
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Inventor(s): Brian Schaefer, Chelsi Beauregard
Keywords(s): Cell Line, Immortalized Macrophages, Macrophage, Mammalian, Viral Vector
Category(s): Research Tool
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Novel, Cross-Sarbecovirus Neutralizing and Binding Monoclonal Antibodies (mAbs) (HJF 660-23)
The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine elicited protection highlights the need to develop vaccine candidates with broad protection. Current invention identified six neutralizing antibodies with broad sarbecovirus cross-reactivity. This finding has applications towards developing next-generation...
Published: 5/9/2025
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Inventor(s): Kerri Lal, Shelly Krebs, Samantha Townsley, Michael Gordon Joyce, Vincent Dussupt
Keywords(s): Antibody, Coronavirus, Cross-Reactivity, Ferritin, Infectious Disease, Nano-particle, Neutralizing Antibodies, Respiratory, Sarbecovirus, SpFN, Spike Proteins, Vaccines, Variants, Viral
Category(s): Research Tool
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Immunogens and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus immunogen that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge.
Applications...
Published: 7/24/2025
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Inventor(s): Shelly Krebs, Vincent Dussupt
Keywords(s): Dengue, Flavivirus, Immunogen, Vaccines, Zika
Category(s): Therapeutic, Diagnostic, Research Tool
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ETV1 Monoclonal Antibodies - (HJF 641-23)
ETV1 is a protein of Erythroblast Transformation Specific (ETS) family of transcription factors. Dysregulation of ETV-1 has been observed in many malignancies including, gastrointestinal stromal (GIS), prostatic tumors, and in triple-negative breast cancer.
Researchers at HJF and the Uniformed Services University for the Health Sciences (USU) have...
Published: 8/18/2025
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Inventor(s): Shyh-Han Tan, Albert Dobi, Shiv Srivastava
Keywords(s): ERG, Monoclonal Antibodies, Prostate Cancer
Category(s): Research Tool, Diagnostic
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SERINC5 Monoclonal Antibodies - (HJF 525-18)
Serine incorporator 5 (SERINC5), is a host cell protein that has been shown to potently reduce HIV-1 infectivity. However, studies related to SERINC5 protein have been challenging due the dearth of high-quality SERINC5-specific monoclonal antibodies (mAbs).
Researchers at the Walter Reed Army Institute of Research (WRAIR) and HJF have developed novel,...
Published: 12/2/2025
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Inventor(s): Victoria Polonis, Michael Gordon Joyce, Sebastian Molnar, Lindsay Wieczorek, Syna Gift
Keywords(s): Monoclonal Antibodies
Category(s): Research Tool
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Rotifer Culture Controller and Algae Doser for Zebrafish Husbandry - (HJF 563-20)
The zebrafish (Danio rerio) has become a popular model organism in biomedical research. Multiple advantages of using this species in biomedicine include high physiological and genetic homology to mammals, external fertilization, rapid development, transparency of embryos and larvae, ease of genetic and other experimental manipulations, as well as cost-...
Published: 7/24/2025
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Inventor(s): Benjamin Garcia
Keywords(s): Algae, Culture, Husbandry, Rotifer, Zebra Fish
Category(s): Research Tool
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Fully Human Skin Substitute with True Human Hair Follicle Neogenesis - (HJF 220-09)
Human skin substitutes available today have varied compositions but generally comprise a nonliving collagen matrix and different combinations of keratinocytes and fibroblasts. However, currently available skin substitutes cannot perform all the functions of normal skin. For example, hair follicle (HF) neogenesis is not observed using any currently available...
Published: 7/24/2025
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Inventor(s): Thomas Darling, Shaowei Li, Rajesh Thangapazham
Keywords(s): Hair Follicle Neogenesis, Human Skin Substitute
Category(s): Research Tool, Therapeutic
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