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Race/Ethnicity associated Biomarkers for Prostate Cancer (HJF 527-18)
Research focused on identifying Race/Ethnicity associated differences of prostate cancer led to the discovery of distinct similarities and differences in gene alterations of African American (AA) and Caucasian American (CA) prostate cancer patients (CaP). These results could lead to the development of a prognostic assay that stratifies newly diagnosed...
Published: 11/28/2025
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Inventor(s): Albert Dobi, Hua Li, Isabell Sesterhenn, Zoltan Szallasi, Shiv Srivastava
Keywords(s): Genomic Alterations, LSAMP, Prostate Cancer, PTEN, Race/Ethnicity Associated Biomarkers,, Recurrence
Category(s): Diagnostic
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Method for Enrichment of Neuronally Derived Extracellular Vesicles (HJF 694-24)
Researchers at the Henry M. Jackson Foundation (HJF) and the Uniformed Services University of the Health Sciences (USU) identified a novel marker (ICAM-5) for enriching neuronally derived extracellular vesicles (NEVs) from human biofluids. NEVs can address key challenges in biomarker identification for neurological disorders.
Applications and Advantages
The...
Published: 10/20/2025
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Inventor(s): Manish Bhomia, Barbara Knollmann-Ritschel
Keywords(s):
Category(s): Diagnostic
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Deiminated Proteins and Their Autoantibodies as Blast TBI Biomarkers (HJF 450-16)
Introduction
Inventors at the Uniformed Services University of the Health Sciences (USU) identified deiminated proteins and their autoantibodies that can be used as potential biomarkers for blast-related traumatic brain injury (TBI). This research addresses a significant health challenge faced by military personnel and athletes who experience repeated...
Published: 12/1/2025
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Inventor(s): Gregory Mueller
Keywords(s): Biomarker
Category(s): Diagnostic
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A Recurrence Gene Signature Across Multiple Cancer Types - (HJF 518-18)
Researchers at the Henry M. Jackson Foundation (HJF), Uniformed Services University of the Health Sciences (USU), Windber Research Institute (CSSIMMW) and Walter Reed National Military Medical Center (WRNMMC) have analyzed a set of biomarkers to identify specific gene signatures that may be predictive for recurrence in breast and ovarian cancers.
Applications...
Published: 7/24/2025
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Inventor(s): Hai Hu, Yi Zhang, Maxwell Lee, Albert Kovatich, Craig Shriver, Xiaoying Lin
Keywords(s): Basal-like breast cancer, BLBC, Breast Cancer, Gene Signature, HGSOC, High-Grade Serous Ovarian Carcinoma, Pan-cancer, Recurrence
Category(s): Diagnostic
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Prostate Cancer Gene Profiles (HJF 346-13)
Prostate cancer (PCa) has the highest heritability and widest racial disparities of any cancer. African Americans (AAs) in the United States are known to have a higher incidence and mortality for PCa compared to Caucasian Americans (CAs).
Researchers at the Henry M. Jackson Foundation (HJF), Uniformed Services University for Health Sciences (USU),...
Published: 8/11/2025
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Inventor(s): Shiv Srivastava, Albert Dobi, Gyorgy Petrovics, Thomas Werner, Martin Seifert, Matthias Scherf
Keywords(s): African American, Ethnic-Specific Genes, Genome Sequencing, Mortality, Prostate Cancer, Prostate Cancer Incidence
Category(s): Diagnostic
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Phosphopeptide Signatures Predicting Basal-Like Breast Cancer Recurrence - (HJF 652-23)
Seventeen (17) phosphopeptides that are significantly differentially expressed between relapsed and relapse-free basal-like breast cancer (BC) tissues, were identified and used to develop a prognostic model with a recurrence index score. This recurrence index score could identify cases of relapsed and relapse-free basal-like BC with a significant difference...
Published: 7/24/2025
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Inventor(s): Albert Kovatich, Hai Hu, Praveen Kumar, Craig Shriver
Keywords(s):
Category(s): Diagnostic
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Non-invasive Clinical Decision Support Tool to Predict Allograft Rejection (HJF 662-23)
Vascularized Composite Allotransplantation (VCA) is a reconstructive option that involves transplantation of composite tissues, such as skin, muscle, and bone, in one surgical procedure. However, graft rejection remains a major challenge that needs to be addressed to improve patient outcomes.
To address this challenge, scientists at Johns Hopkins University...
Published: 9/15/2025
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Inventor(s): Renhua Li, Gerald Brandacher, Eric Elster, Seth Schobel-McHugh, Byoung Chol Oh
Keywords(s): Allograft rejection, Graft Failure, Reconstruction
Category(s): Diagnostic
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Diagnostic Tool for High-grade Serous Ovarian Cancer - (HJF 616-21)
Researchers at HJF, Inova Fairfax Hospital (IFH), and the Peter MacCallum Cancer Centre (PMCC) have identified orthogonal protein and transcript-based biomarkers correlating with Homologous Recombination Deficiency (HRD). This may lead to a companion clinical diagnostic assay to prioritize High-Grade Serous Ovarian Cancer (HGSOC) patients for targeted...
Published: 8/22/2025
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Inventor(s): Nicholas Bateman, Tamara Abulez, Thomas Conrads, George Larry Maxwell, Dale Garsed, David Bowtell, Ahwan Pandey
Keywords(s): Assay, Biomarker Assay, Companion Diagnostic, DDR, DNA Damage Repair, HGSOC, High-Grade Serous Ovarian Carcinoma, Ovarian Cancer, PARP Inhibitors
Category(s): Therapeutic, Diagnostic
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Immunogens and Vaccine Compositions Against Flavivirus - (HJF 624-22)
HJF researchers have developed a novel recombinant flavivirus immunogen that can induce immunogenicity against multiple flaviviruses, including ZIKV (Zika) and DENV (dengue), without life-threatening antibody-dependent enhancement (ADE) responses. Mice immunized with this recombinant immunogen were protected from lethal ZIKV challenge.
Applications...
Published: 7/24/2025
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Inventor(s): Shelly Krebs, Vincent Dussupt
Keywords(s): Dengue, Flavivirus, Immunogen, Vaccines, Zika
Category(s): Therapeutic, Diagnostic, Research Tool
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DNA Damage Repair Genes in Prostate Cancer - (HJF 557-19)
Prostate cancer patients with DDRG mutations are increasingly considered for targeted cancer therapies. Currently available DDRG mutation tests rely on a rather small number of genes which are not often mutated in African American prostate cancer patients. This invention describes a robust data set on inherited mutations which can be used to develop...
Published: 7/24/2025
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Inventor(s): Gyorgy Petrovics, Shiv Srivastava
Keywords(s): African American, Caucasian, DDRG, Mutation, Precision Therapy, Prostate Cancer
Category(s): Diagnostic
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